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2 edition of Characterization of thyroglobulin found in the catalog.

Characterization of thyroglobulin

Catherine A. Hanham

Characterization of thyroglobulin

by Catherine A. Hanham

  • 63 Want to read
  • 37 Currently reading

Published by University of Birmingham in Birmingham .
Written in English


Edition Notes

Thesis (Ph.D.) - University of Birmingham, Dept of Medicine.

StatementCatherine A. Hanham.
ID Numbers
Open LibraryOL13869931M

An in Vitro Model for Thyroid Autoimmunity.- Genetic Aspects of Graves' Disease.- Thyroid and Related Autoimmune Disorders: Challenging the Dogmas.- Molecular and Functional Characterization of Genes Encoding Anti-Thyroglobulin and Anti-TSH Receptor Antibodies.- Autoantigenicity of Murine Thyroglobulin Thyroglobulin, TSH receptor, and E-cadherin mRNA accumulations were not modified in a consistent way, which confirms the near-constitutive expression of the corresponding genes in normal differentiated tissue. On the contrary, early immediate genes expressions (c-myc, NGF1B, egr 1, genes of the fos and jun families) were decreased. This may be Cited by:

  Thyroglobulin is a large protein present in all vertebrates. It is synthesized in the thyrocytes and exported to lumen of the thyroid follicle, where its tyrosine residues are iodinated. The iodinated thyroglobulin is reintegrated into the cell and processed (cleaved to free its two extremities) for thyroid hormone synthesis. Thyroglobulin sequence analysis has identified four regions of the Cited by: 7. Thyroglobulin (Tg), the most important and abundant protein in thyroid follicles, is well known for its essential role in thyroid hormone synthesis. In addition to its conventional role as the precursor of thyroid hormones, we have uncovered a novel function of Tg as an endogenous regulator of follicular function over the past decade. The newly discovered negative feedback effect of Tg on Cited by: 9.

BOOK. 1. J. Chae, “High “Microfluidic biosensors for thyroglobulin detection and application to thyroid cancer,” Biosensors and Cancer Chae, J. Giachino, and K. Najafi, “Fabrication and Characterization of a Wafer-Level MEMS Vacuum Package with Vertical Feedthroughs”, IEEE Journal of Microelectromechanical Systems. The characterization of normal thyroid tissue by micro-FTIR spectroscopy a protein structural heterogeneity that can be correlated with the spatially resolved amount of iodine in the thyroglobulin structure of colloids and follicular cells. books or book chapters) do not need to formally request permission to reproduce material Cited by:


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Characterization of thyroglobulin by Catherine A. Hanham Download PDF EPUB FB2

Thyroglobulin (Tg) is a kDa, dimeric protein produced by the follicular cells of the thyroid and used entirely within the thyroid gland. Thyroglobulin protein accounts for approximately half of the protein content of the thyroid gland.

Each thyroglobulin molecule contains approximately tyrosyl (Tyrosine) residues. Thyroglobulin (Tg) is the large ( kDa) glycoprotein that is synthesized exclusively by thyroid follicular cells and serves as the scaffold for thyroid hormonogenesis.

As thyroid cells are assumed to be the only source of thyroglobulin (Tg) in the human body, circulating Tg serves as a biochemical marker of persistent or recurrent disease in DTC follow-up. Currently, standard follow-up of DTC comprises Tg measurement and neck ultrasound combined, when indicated, with an additional radioiodine : Luca Giovanella, Federica D’Aurizio, Renato Tozzoli, Camilla Schalin-Jantti, Ulla Feldt-Rasmussen.

Thyroglobulin, a large glycoprotein molecule measuringKd 1,2 is a product unique to the follicular cells of the thyroid gland. Because of its easy accessibility, it has been the subject of numerous studies since its discovery in Thyroglobulin functions as the location of thyroid hormone synthesis and storage.

The number of thyroglobulin-binding peripheral blood cells (TG-BL) was determined in 24 patients with Hashimoto thyroiditis: 12 non-Hashimoto, non-Graves disease goiter patients; and 10 unrelated controls using the fluoroimmunocytoadherence (FICA) by: 6.

Thyroglobulin (Tg) epitopes of serum Tg autoantibodies (TgAb) have been characterized using inhibition of Tg binding by human monoclonal TgAb in autoimmune thyroid diseases (AITD) [Hashimoto's. The thyroglobulin promoter has been characterised in the human, canine and bovine species and in the rat and mouse.

The cell type specific activity of the thyroglobulin promoter was first demonstrated in vitro by Musti et al., investigating the rat by: 7. The anti-thyroglobulin specificity of the antibodies showing macroglobulin character was ascertained by absorption experiments with human thyroglobulin; it was ruled out by absorption with FII that the 19S character might result from the formation of complexes with anti-γ-globulin by: 9.

" The thyroglobulin antibodies present in the sera of thirteen leprosy patients were shown to be exclusively or predominantly macroglobulin in character when studied by diethylaminoethylcellulose chromatography and preparative ultracentrifugation. This was confirmed by immunoelectrophoresis and analytical ultracentrifugation of the fractions containing thyroglobulin antibodies, as well as by Cited by: 9.

Bovine thyroglobulin is a large, tetrameric glycoprotein produced in the thyroid gland as a precursor to thyroid hormones. Its large size and absence from plasma under normal conditions makes it very immunogenic and reduces the chance that antibodies to this carrier protein will cross-react with plasma proteins in immunoassays.

Thyroglobulin (Tg) is a marker of tumor recurrence during thyroid cancer follow-up. While helpful in the postoperative setting, the clinical significance of preoperative Tg measurements remains unclear.

The aim of the study was to determine if preoperative Tg levels are indicative of underlying malignancy or burden of metastatic by: 8.

Thyroglobulin ( kDa), the major protein of the camel thyroid, has been isolated and purified from saline extract of the gland by ammonium sulfate fractionation and DEAE-cellulose chromatography. Characterization of Thyroglobulin-Directed and Polyreactive Catalytic Antibodies in Autoimmune Disease Article (PDF Available) in The Journal of Immunology (3).

The thyroglobulin (Tg) gene is encoded by human chromosome 8q–8q in a kb coding sequence covering 48 exons. As illustrated in Fig, transcription of the kDa Tg monomeric protein. Thyroglobulin (Tg) is a kDa, dimeric glycoprotein produced by the follicular cells of the thyroid and used entirely within the thyroid gland.

Tg is secreted and accumulated at hundreds of grams per litre in the extracellular compartment of the thyroid follicles, accounting for approximately half of the protein content of the thyroid gland. Human TG (hTG) is a homodimer of subunits each Aliases: TG, AITD3, TGN, thyroglobulin.

PDF | The Thyroglobulin (TG) and Leptin (LEP) genes are two candidate genes that widely used for molecular selection to improve carcass traits in beef | Find, read and cite all the research you.

The release of thyroglobulin from the thyroid gland into the thyroid lymphatics; the identification of thyroglobulin in the thyroid lymph and in the blood of monkeys by physical and immunological methods and estimation by by: 5. characterization of anti-thyroglobulin factors in human serum John L.

Fahey and Howard C. Goodman Metabolism Service, General Medicine Branch, National Cancer Institute, Bethesda, by: Isolation and partial characterization of a porcine thyroglobulin-binding Phaseolus vulgaris L.

lectin. Food Chemistry44 (3), DOI: /(92)Cited by: Thyroglobulin is a protein produced by both normal and cancerous thyroid cells. Treatment of thyroid cancer frequently involves total thyroidectomy and radioiodine therapy followed by thyroid hormone therapy to suppress serum TSH and turn off any residual normal thyroid cells.

Abstract. The thyroglobulin (Tg) gene is encoded by human chromosome 8q–8q in a kb coding sequence covering 48 exons. As illustrated in Fig.transcription of the kDa Tg monomeric protein is regulated by a number of transcription factors that include TTF-1, TTF-2, and Pax-8 .Request PDF | Characterization of the feline thyroglobulin promoter | The feline thyroglobulin promoter was identified by a combination of standard polymerase chain reaction (PCR) techniques.An immune phage library derived from mice, hyperimmunized with morphine-conjugated BSA, was used to isolate a single-chain Fv (scFv) clone, M86, with binding activity to morphine-conjugated thyroglobulin (morphine-C-Tg) but not to codeine- cocaine- or ketamine-conjugated Tg.

Surface plasmon resonance analysis using a morphine-C-Tg-coupled CM5 sensor chip showed that the Kd value was Cited by: 1.